The Neurobiology of Body Dysmorphic Disorder

What do you know about the neurobiological bases underlying body dysmorphic disorder? We examine them in this article.
The Neurobiology of Body Dysmorphic Disorder

Written by José Padilla

Last update: 24 November, 2022

Body dysmorphic disorder (BDD) is characterized by an excessive preoccupation with one or more physical characteristics. In effect, the individual identifies in themselves a physical defect and overestimates its importance in the social sphere (APA, 2014).

Those who suffer from this disorder spend a great deal of time focusing on their imperfections and how to hide them. In fact, their negative thoughts take up most of their days. Furthermore, they interfere with their quality of life and ability to carry out their daily activities.

The prevalence of BDD ranges between 0.7 and 2.5 percent of the population, reaching 12 percent in obsessive-compulsive patients. With regard to gender, the prevalences are rather similar. That said,  there are slight differences in the parts of the body that cause concern. For instance, in men, the most commonly perceived defects concern the genitals, body structure, and hair. On the other hand, in women, they usually involve the skin, abdomen, and how much they weigh. (Rincon, 2022).

In this article, we’ll address the neurobiological basis of the disorder. We’ll also review the claims of certain research regarding its etiology at the cortical level.

Woman looking in the mirror with fear
People with BDD show excessive concern regarding their own body image.

The left hemisphere of the brain in people with BDD

One study identified no significant alterations in the brains of people with BDD. However, it suggested that sufferers function abnormally when processing visual details. This finding was one of the first to support the idea that a neurobiological correlate exists for the distorted body image of patients with this disorder.

“Our discovery suggests that the hardware of the BDD brain is fine, but there is a flaw in the operating software that prevents patients from seeing themselves as others do” explained lead researcher, Jamie Feusner, MD.

The researchers used functional magnetic resonance imaging (fMRI) to observe how the sufferers’ brains processed visual information. To do this, they equipped 12 patients with BDD with special glasses. They were asked to view digital photos of various faces while their brains were scanned.

Each participant viewed three types of images. The first type was an intact photo. The second kind was a photo altered to remove facial details, such as freckles, wrinkles, and scars. The third type had significantly altered faces.

A surprising find

The researchers compared the responses of BDD patients with 12 control subjects. Their observations were surprising.

“We saw a clear difference in how the left and right sides of the brain functioned in people with BDD compared to those without the disorder” Feusner said.

In fact, the BDD patients used the left sides of their brains more often. This is the analytical side, attuned to complex details. However these patients used it even when processing less complex, low-frequency images. Indeed, their left hemispheres were activated regardless of the type of image viewed. In contrast, in healthy people, the left side was only activated to interpret information from the most altered images.

“The findings suggest that brains with BDD are hardwired to extract details, or fill in details where none exist. They may be thinking of their own face even when looking at others” Feusner claimed.

The study also found that limitations in number and severity were positively associated with the intensity with which the left hemisphere was activated during visual processing.

Neurocognitive functioning in body dysmorphic disorder

In 1998, Hanes found that people with BDD and OCD performed poorly in tests of executive function, including response inhibition and planning. Moreover, a 2010 study found that participants with BDD made significantly more errors on spatial working memory tasks. They also exhibited slower thinking times in a Stockings of Cambridge test, used to investigate deficits in memory planning.

Other neuropsychological studies in people with body dysmorphic disorder have highlighted that these patients appear to possess deficits in facial recognition of emotions. In fact, research has shown that in self-referential situations, patients with BDD are more likely to misinterpret neutral faces as angry or dismissive.

The neurochemistry of brains with BDD

A reduction in the serotonin transporter has been found in disorders related to OCD, including BDD. In addition, results of various studies indicate that serotonin reuptake inhibitors (SSRIs) are effective for the treatment of BDD (Ipser, 2010; Phillips & Hollander, 2008).

Furthermore, SSRI treatment reduces the frequency and intensity of worry. It also improves control over impulsivity and decreases the distress associated with BDD (Allen et al., 2008; Phillips & Hollander, 2008).

Other studies on the role of serotonin in BDD indicate that the symptoms of this disorder intensify as tryptophan (the precursor of serotonin) in the diet is reduced. They also claim that psilocybin, a serotonin agonist, reduces the symptoms of body dysmorphic disorder.

Blue lit brain
BDD symptoms intensify when tryptophan decreases.

The neuroanatomy of body dysmorphic disorder

Research conducted by Grace in 2017 and 2019 demonstrated that patients with BDD had hypoactivity in the lateral occipital cortex (related to visual processes) and the precuneus (related to face recognition). This was more particularly evident in the left hemisphere. It affects the visual processing of information associated with faces and figures. Other research revealed a possible alteration in the frontostriatal and temporal-parietal-occipital circuits (where facial images and emotional information are processed).

Taking the above into account, Li et al. (2013) stated that visual perceptual disturbances, along with frontostriatal and limbic system dysfunction, may combine to contribute to BDD symptoms such as perceptual impairment, obsessive thoughts, and compulsions.

Finally, body dysmorphic disorder is a complex psychiatric disorder in which various environmental and biological factors converge. Its neurobiological basis isn’t yet clear and definitive. However, the results of the research reviewed here give us a certain insight into understanding a little more about how the brains of sufferers work.

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  • Allen, A., Hadley, S. J., Kaplan, A., Simeon, D., Friedberg, J., Priday, L., … & Hollander, E. (2008). An open-label trial of venlafaxine in body dysmorphic disorder. CNS spectrums13(2), 138-144.
  • American Psychiatric Association [APA]. (2014). Manual diagnóstico y estadístico de los trastornos mentales (5ª ed.). Editorial médica panamericana.
  • Behar, R., Arancibia, M., Heitzer, C., & Meza, N. (2016). Trastorno dismórfico corporal: aspectos clínicos, dimensiones nosológicas y controversias con la anorexia nerviosa. Revista médica de Chile144(5), 626-633.
  • Buhlmann, U., Etcoff, N. L., & Wilhelm, S. (2006). Emotion recognition bias for contempt and anger in body dysmorphic disorder. Journal of Psychiatric Research40(2), 105-111.
  • Dunai, J., Labuschagne, I., Castle, D. J., Kyrios, M., & Rossell, S. L. (2010). Executive function in body dysmorphic disorder. Psychological medicine40(9), 1541-1548.
  • Feusner, J. D., Townsend, J., Bystritsky, A., & Bookheimer, S. (2007). Visual information processing of faces in body dysmorphic disorder. Archives of general psychiatry64(12), 1417-1425.
  • Grace, S. A., Labuschagne, I., Kaplan, R. A., & Rossell, S. L. (2017). The neurobiology of body dysmorphic disorder: A systematic review and theoretical model. Neuroscience & Biobehavioral Reviews83, 83-96.
  • Grace, S. A., Toh, W. L., Buchanan, B., Castle, D. J., & Rossell, S. L. (2019). Impaired recognition of negative facial emotions in body dysmorphic disorder. Journal of the International Neuropsychological Society25(8), 884-889.
  • Hanes, K. R. (1998). Neuropsychological performance in body dysmorphic disorder. Journal of the International Neuropsychological Society4(2), 167-171.
  • Ipser, J. C., Sander, C., & Stein, D. J. (2009). Pharmacotherapy and psychotherapy for body dysmorphic disorder. Cochrane Database of Systematic Reviews, (1).
  • Li, W., Arienzo, D., & Feusner, J. D. (2013). Body dysmorphic disorder: neurobiological features and an updated model. Zeitschrift fur klinische Psychologie und Psychotherapie (Gottingen, Germany)42(3), 184.
  • Marazziti, D., Dell’Osso, L., Presta, S., Pfanner, C., Rossi, A., Masala, I., … & Cassano, G. B. (1999). Platelet [3H] paroxetine binding in patients with OCD-related disorders. Psychiatry research89(3), 223-228.
  • Perkins, A. (2019). Trastorno dismórfico corporal. La búsqueda de la perfección. Nursing (Ed. española)36(6), 16-20.
  • Phillips, K. A., & Hollander, E. (2008). Treating body dysmorphic disorder with medication: evidence, misconceptions, and a suggested approach. Body image5(1), 13-27.
  • Rincon, D. (2022). Dimensión histórica, síntomas y neurobiología del trastorno dismórfico corporal. Psychologia16(1), 49-56.
  • University of California in Los Angeles (UCLA). Distorted self-image the result of visual brain glitch, study finds.

The contents of Exploring Your Mind are for informational and educational purposes only. They don't replace the diagnosis, advice, or treatment of a professional. In the case of any doubt, it's best to consult a trusted specialist.