Meninges: Structure and Functions

The pia is the innermost layer of the meninges. It's a delicate vascular structure that surrounds and adheres to the surface of the brain and spinal cord.
Meninges: Structure and Functions

Last update: 29 June, 2020

The brain and spinal cord are surrounded by three membranous layers: the meninges. The three meninges are the dura mater, the arachnoid mater, and the pia mater. The last two comprise the leptomeninges. The dura mater is also called the pachymeninx.

The main function of the meninges is to protect the brain. T his is a very vulnerable organ that needs special protection. No other organ needs it, at least not in the same way. In addition, these protective layers are part of the blood-brain barrier.

The meninges stem from another layer known as primitive meninx, which is composed of elements derived from mesenchyme and neural crest. The primitive meninx is separated into two distinct layers: the internal (endomeninx) and the external (ectomeninx).

The endomeninx is different from the arachnoid mater and the pia mater and it derives from both the mesoderm and the ectoderm. On the other hand, the ectomeninx forms the dura mater and the bones of the neurocranium and is composed of only the mesoderm.

Central nervous system.

Structure of the meninges

The dura mater

The dura mater is the outermost layer of the meninges and it has two layers. The outer layer is the periosteum and contains blood vessels and nerves. It adheres to the internal surface of the skull, with joints especially adjusted to the base of the skull.

The name of the deepest layer of the dura mater is the meningeal layer. It’s responsible for the reflexes that divide the brain into compartments.

Among these compartments, the most prominent are: the falx cerebri and tentorium cerebelli. In addition, there’s no distinctive border between the dura mater and the periosteum. The layers distinguish themselves histologically by the fact that the meningeal layer has fewer fibroblasts and proportionally less collagen (2).

The arachnoid mater

The arachnoid is the middle layer of the meninges. It contains the subarachnoid space that in turn stores cerebrospinal fluid (CSF). The depth of the subarachnoid space varies depending on the relationship between the arachnoid mater and the pia mater.

Two separate cell layers form the arachnoid mater. The arachnoid barrier cells layer is located following the edge of the cells of the dura mater (3). This layer is full of cells closely linked by numerous desmosomes and tight junctions. Thus, this layer keeps fluid from moving through it.

The reticular arachnoid layer is deep inside the arachnoid mater. Its cells connect the subarachnoid space and attach to the pia mater. They also enclose the blood vessels that pass through the layer (1).

Arachnoid villi are microscopic structures that play an important role in the absorption of CSF. However, the way they work is unclear. Some believe that arachnoid villi may also play a role in regulating CSF volume.

Pia mater

The pia mater is the innermost layer of the meninges. It’s a delicate vascular structure that surrounds and adheres to the surface of the brain and spinal cord and protects it.

It creates a continuous layer of cells that attach to the surface of the brain and then submerges in the fissures and grooves of the brain. Desmosomes and gap junctions link the cells, which allows the layer to function as a barrier.

Virchow-Robin spaces

Virchow-Robin spaces are located around the vessels and surround the small arteries and the arterioles. They pierce the surface of the brain and extend inward from the subarachnoid space (1).

These spaces increase in size as they age without an apparent associated loss of cognitive function (4). In addition, the dilation of these spaces is related to conditions such as hypertension, neuropsychiatric disorders, multiple sclerosis, and trauma (5).

To conclude, authors Patel and Kirmi (2009) emphasized the importance of knowing about the meninges. It’s essential to understand their structure, functions, and anatomy because it’ll allow us to understand the pathologies related to the meninges.


All cited sources were thoroughly reviewed by our team to ensure their quality, reliability, currency, and validity. The bibliography of this article was considered reliable and of academic or scientific accuracy.


  • Patel, N., & Kirmi, O. (2009). Anatomy and imaging of the normal meninges. In Seminars in Ultrasound, CT and MRI (Vol. 30, No. 6, pp. 559-564). WB Saunders.
  • Haines, D. E., Harkey, H. L., & Al-Mefty, O. (1993). The “subdural” space: a new look at an outdated concept. Neurosurgery, 32(1), 111-120.
  • Alcolado, R., Weller, R. O., Parrish, E. P., & Garrod, D. (1988). The cranial arachnoid and pia mater in man: anatomical and ultrastructural observations. Neuropathology and applied neurobiology, 14(1), 1-17.
  • Groeschel, S., Chong, W. K., Surtees, R., & Hanefeld, F. (2006). Virchow-Robin spaces on magnetic resonance images: normative data, their dilatation, and a review of the literature. Neuroradiology, 48(10), 745-754.
  • Kwee, R. M., & Kwee, T. C. (2007). Virchow-Robin spaces at MR imaging. Radiographics, 27(4), 1071-1086.

This text is provided for informational purposes only and does not replace consultation with a professional. If in doubt, consult your specialist.